I read it, but I don't know if I liked it.  Heck, I'm not sure that over the course of the book if I ever really figured out what was going on.  Nevertheless, I would still recommend it for those guys who can handle rough language and weird situations.

John Dies In the End is the story of David Wong, a young man who happens to gotten involved with mysterious dark forces seeking to take over our world.  First, it seems like a simple case of a few hauntings and vision he sees after ingesting some weird soy sauce-type stuff.  But then it gets weird.  Lovecraftian weird.  His dog explodes, but comes trotting up merrily afterwards.  A trip to a self-improvement guru in Vegas ends up with him and his buddies dressed as the band "Elton John" and a vortex sucking in a bunch of people who turn out to never have existed.

Possible dimensional travel, demons and a monster called "Korrok" all mix together and leave a confusing trail of oddities.  I can't say it all makes sense, but it's an entertaining enough read, with the author bring a fair amount of irreverence, much like his work on Cracked.com, which I've referenced a couple of times before, and of which David Wong is the senior editor.

A sequel is due out in October called This Book is Full of Spiders: Seriously Dude, Don't Touch It.

It will eventually be released as a film that will likely become a cult hit.